ABSTRACT
Abstract Purpose To identify whether the colon mucosa is affected by ten days of gastric restriction in an animal model. Methods An experimental model of gastric restriction was devised using rats. The animals were submitted to surgical gastrostomy, and a cylindrical loofah was inserted into the stomach. We studied 30 adult male Wistar rats divided into three groups: the stomach restriction group (R10); the sham group (S10), which underwent the same procedure except for the loofah insertion; and the control group (C10). The expression of neutral and acid mucins was evaluated using histochemical techniques. Goblet cells and protein content were compared between groups using generalized estimation equations (GEEs). Bonferroni's multiple comparison was applied to identify differences between the groups. All tests considered a 5% significance level. Results There was an increased expression of neutral mucins, acid mucins and goblet cells in the R10 group. Collagen was also enhanced in the R10 group. Conclusion The colon mucosa is affected by ten days of gastric restriction in an animal model, increasing neutral mucins, acid mucins and collagen content with trophic maintenance.
Subject(s)
Animals , Male , Rats , Food Deprivation , Intestinal Mucosa/metabolism , Mucins/metabolism , Time Factors , Gastrostomy , Rats, Wistar , Colon , Models, Animal , Intestinal Mucosa/pathologyABSTRACT
Este estudo tem como objetivo verificar as medidas externas e internas na técnica da introdução do cateter nasoenteral, e os respectivos locais de fixação da ponta distal deste tubo. Trata-se de uma pesquisa descritiva, em que realizamos a medida padrão, externa e interna no tubo digestório de quatro cadáveres, realizando as medidas até a porção pós-pilórica no intestino delgado. A literatura descreve algumas técnicas de medida padrão, ponta nariz/lóbulo orelha/processo xifóide, deve ser acrescida de 10 a 50cm. Concluímos que em relação a esta medida, apesar dos dados da literatura serem divergentes, este trabalho aponta para uma padronização de 50 cm que deverá ser acrescida após o processo xifóide.